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2024-12-31T01:17:34-0500
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Apalutamideapalutamide will decrease the level or effect of sildenafil by affecting hepatic intestinal enzyme CYP3A4 metabolism.
When sildenafil is taken with a high fat meal, the rate of absorption is reduced with a mean delay in Tmax of 60 minutes and a mean reduction in Cmax of 29.